Version 5.4
Homo sapiens Gene: SFRP5
Summary
InnateDB Gene IDBG-85742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFRP5
Gene Name secreted frizzled-related protein 5
Synonyms SARP3
Species Homo sapiens
Ensembl Gene ENSG00000120057
Encoded Proteins
IDBP-85744
secreted frizzled-related protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:97766751-97771952
Strand Reverse strand
Band q24.2
Transcripts
ENST00000266066 ENSP00000266066
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001944 vasculature development
GO:0006915 apoptotic process
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007420 brain development
GO:0007601 visual perception
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0009653 anatomical structure morphogenesis
GO:0030154 cell differentiation
GO:0035414 negative regulation of catenin import into nucleus
GO:0036342 post-anal tail morphogenesis
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043508 negative regulation of JUN kinase activity
GO:0048546 digestive tract morphogenesis
GO:0051898 negative regulation of protein kinase B signaling
GO:0060028 convergent extension involved in axis elongation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090175 regulation of establishment of planar polarity
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000057 negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018822
View Gene Order
ENSBTAG00000018566
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q5T4F7
TrEMBL
UniProt Splice Variant
Entrez Gene 6425
UniGene Hs.279565
RefSeq NM_003015
HUGO HGNC:10779
OMIM 604158
CCDS CCDS7472
HPRD 09166
IMGT
EMBL AF017988 AF117758 AL358938 BC050435 CR596705
GenPept AAB70794 AAD25052 AAH50435 CAI14274
RNA Seq Atlas 6425

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca