InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SFRP5

Summary

InnateDB Gene

IDBG-638478.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP5

Gene Name

Secreted frizzled-related protein 5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018566

Encoded Proteins

IDBP-690545

Secreted frizzled-related protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120057:
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:18782564-18787376

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024709

ENSBTAP00000024709

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0035414	negative regulation of catenin import into nucleus
GO:0036342	post-anal tail morphogenesis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043508	negative regulation of JUN kinase activity
GO:0048546	digestive tract morphogenesis
GO:0051898	negative regulation of protein kinase B signaling
GO:0060028	convergent extension involved in axis elongation
GO:0060070	canonical Wnt signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090175	regulation of establishment of planar polarity
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000057	negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000120057

View Gene Order

ENSMUSG00000018822

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04310

Wnt signaling pathway pathway

mmu04310

Wnt signaling pathway pathway

INOH

INOH website

Wnt signaling pathway pathway

PID NCI

Cross-References

SwissProt

Q9XSC1

TrEMBL

UniProt Splice Variant

Entrez Gene

282069

UniGene

Bt.3968

RefSeq

NM_174461

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF117757 BC149165

GenPept

AAD25051 AAI49166

RNA Seq Atlas

282069