Version 5.4
Homo sapiens Gene: ELF4
Summary
InnateDB Gene IDBG-85951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELF4
Gene Name E74-like factor 4 (ets domain transcription factor)
Synonyms ELFR; MEF
Species Homo sapiens
Ensembl Gene ENSG00000102034
Encoded Proteins
IDBP-85953
E74-like factor 4 (ets domain transcription factor)
IDBP-85955
E74-like factor 4 (ets domain transcription factor)
IDBP-380853
E74-like factor 4 (ets domain transcription factor)
IDBP-807319
E74-like factor 4 (ets domain transcription factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24185615
After viral infection, ELF4 binds to TMEM173 (STING) and induces type I interferon. ELF4 is critical for host antiviral defense.
Entrez Gene
Summary The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:130064874-130110716
Strand Reverse strand
Band q26.1
Transcripts
ENST00000335997 ENSP00000338608
ENST00000308167 ENSP00000311280
ENST00000434609 ENSP00000407572
ENST00000615377 ENSP00000478297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001787 natural killer cell proliferation
GO:0001866 NK T cell proliferation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031103
View Gene Order
ENSBTAG00000019061
Not yet available
Cross-References
SwissProt Q99607
TrEMBL B1AL80
UniProt Splice Variant
Entrez Gene 2000
UniGene Hs.271940 Hs.623574
RefSeq NM_001127197 XM_005262389 NM_001421
HUGO HGNC:3319
OMIM 300775
CCDS CCDS14617
HPRD 06499
IMGT
EMBL AF000670 AL136450 BC017194 CH471107 U32645 Z81363
GenPept AAB53693 AAC17452 AAH17194 CAI42371 CAI42882 EAX11813 EAX11814
RNA Seq Atlas 2000

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca