InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELF4

Summary

InnateDB Protein

IDBP-85953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELF4

Protein Name

E74-like factor 4 (ets domain transcription factor)

Synonyms

ELFR; MEF;

Species

Homo sapiens

Ensembl Protein

ENSP00000338608

InnateDB Gene

IDBG-85951 (ELF4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. {ECO:0000250, ECO:0000269PubMed:10207087, ECO:0000269PubMed:14625302, ECO:0000269PubMed:14976184, ECO:0000269PubMed:19380490, ECO:0000269PubMed:8895518, ECO:0000269PubMed:9524226}.

Subcellular Localization

Nucleus, PML body {ECO:0000269PubMed:14976184}. Note=Accumulation into PML nuclear bodies is mediated by PML.

Disease Associations

Note=A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

Tissue Specificity

Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. {ECO:0000269PubMed:8895518, ECO:0000269PubMed:9524226}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001787	natural killer cell proliferation
GO:0001866	NK T cell proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter