Version 5.4
Homo sapiens Gene: DNMBP
Summary
InnateDB Gene IDBG-86220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNMBP
Gene Name dynamin binding protein
Synonyms ARHGEF36; TUBA
Species Homo sapiens
Ensembl Gene ENSG00000107554
Encoded Proteins
IDBP-86226
dynamin binding protein
IDBP-384316
dynamin binding protein
IDBP-590510
dynamin binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions (Otani et al., 2006 [PubMed 17015620]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:99875577-100009919
Strand Reverse strand
Band q24.2
Transcripts
ENST00000324109 ENSP00000315659
ENST00000422692 ENSP00000409476
ENST00000472036
ENST00000543621 ENSP00000443657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005795 Golgi stack
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025195
View Gene Order
ENSBTAG00000008939
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.500771 Hs.626352
RefSeq NM_015221 XM_006717736
HUGO
OMIM
CCDS CCDS7485
HPRD 10918
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca