InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNMBP

Summary

InnateDB Protein

IDBP-590510.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMBP

Protein Name

dynamin binding protein

Synonyms

ARHGEF36; TUBA;

Species

Homo sapiens

Ensembl Protein

ENSP00000443657

InnateDB Gene

IDBG-86220 (DNMBP)

Protein Structure

UniProt Annotation

Function

Scaffold protein that links dynamin with actin- regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localized to synapses and Golgi stacks. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:14506234}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction