InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HES5

Summary

InnateDB Gene

IDBG-86393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HES5

Gene Name

hairy and enhancer of split 5 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000197921

Encoded Proteins

IDBP-86395

hairy and enhancer of split 5 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:2528745-2530245

Strand

Reverse strand

Band

p36.32

Transcripts

ENST00000378453

ENSP00000367714

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007219	Notch signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0014003	oligodendrocyte development
GO:0021537	telencephalon development
GO:0021781	glial cell fate commitment
GO:0021861	forebrain radial glial cell differentiation
GO:0021915	neural tube development
GO:0022010	central nervous system myelination
GO:0030182	neuron differentiation
GO:0030513	positive regulation of BMP signaling pathway
GO:0031641	regulation of myelination
GO:0042491	auditory receptor cell differentiation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668	auditory receptor cell fate determination
GO:0043010	camera-type eye development
GO:0045595	regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0048469	cell maturation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048708	astrocyte differentiation
GO:0048712	negative regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050767	regulation of neurogenesis
GO:0051216	cartilage development
GO:0072049	comma-shaped body morphogenesis
GO:0072050	S-shaped body morphogenesis
GO:0072086	specification of loop of Henle identity
GO:0072282	metanephric nephron tubule morphogenesis
GO:0097150	neuronal stem cell maintenance
GO:2000737	negative regulation of stem cell differentiation
GO:2000974	negative regulation of pro-B cell differentiation
GO:2000978	negative regulation of forebrain neuron differentiation
GO:2000981	negative regulation of inner ear receptor cell differentiation