InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HES5

Summary

InnateDB Protein

IDBP-86395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HES5

Protein Name

hairy and enhancer of split 5 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367714

InnateDB Gene

IDBG-86393 (HES5)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in fetal heart and brain tumors. {ECO:0000269PubMed:15254753}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007219	Notch signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0014003	oligodendrocyte development
GO:0021537	telencephalon development
GO:0021781	glial cell fate commitment
GO:0021861	forebrain radial glial cell differentiation
GO:0021915	neural tube development
GO:0022010	central nervous system myelination
GO:0030182	neuron differentiation
GO:0030513	positive regulation of BMP signaling pathway
GO:0031641	regulation of myelination
GO:0042491	auditory receptor cell differentiation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668	auditory receptor cell fate determination
GO:0043010	camera-type eye development
GO:0045595	regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0048469	cell maturation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048708	astrocyte differentiation
GO:0048712	negative regulation of astrocyte differentiation
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050767	regulation of neurogenesis
GO:0051216	cartilage development
GO:0072049	comma-shaped body morphogenesis
GO:0072050	S-shaped body morphogenesis
GO:0072086	specification of loop of Henle identity
GO:0072282	metanephric nephron tubule morphogenesis
GO:0097150	neuronal stem cell maintenance
GO:2000737	negative regulation of stem cell differentiation
GO:2000974	negative regulation of pro-B cell differentiation
GO:2000978	negative regulation of forebrain neuron differentiation
GO:2000981	negative regulation of inner ear receptor cell differentiation