Version 5.4
Homo sapiens Gene: SCD
Summary
InnateDB Gene IDBG-86483.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCD
Gene Name stearoyl-CoA desaturase (delta-9-desaturase)
Synonyms FADS5; MSTP008; SCD1; SCDOS
Species Homo sapiens
Ensembl Gene ENSG00000099194
Encoded Proteins
IDBP-86485
stearoyl-CoA desaturase (delta-9-desaturase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100347124-100364834
Strand Forward strand
Band q24.31
Transcripts
ENST00000370355 ENSP00000359380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 6 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004768 stearoyl-CoA 9-desaturase activity
GO:0005506 iron ion binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt O00767
TrEMBL
UniProt Splice Variant
Entrez Gene 6319
UniGene Hs.558396 Hs.734527
RefSeq NM_005063
HUGO HGNC:10571
OMIM 604031
CCDS CCDS7493
HPRD
IMGT
EMBL AB032261 AF097514 AF320307 AK222862 AK312312 AL139819 BC005807 BC062303 CH471066 S70284 Y13647
GenPept AAB30631 AAD29870 AAH05807 AAH62303 AAK54510 BAA93510 BAD96582 BAG35237 CAA73998 CAH72823 CAH72824 EAW49829 EAW49830
RNA Seq Atlas 6319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca