InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCD

Summary

InnateDB Protein

IDBP-86485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCD

Protein Name

stearoyl-CoA desaturase (delta-9-desaturase)

Synonyms

FADS5; MSTP008; SCD1; SCDOS;

Species

Homo sapiens

Ensembl Protein

ENSP00000359380

InnateDB Gene

IDBG-86483 (SCD)

Protein Structure

UniProt Annotation

Function

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	6 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004768	stearoyl-CoA 9-desaturase activity
GO:0005506	iron ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR005804 Fatty acid desaturase, type 1
IPR015876 Fatty acid desaturase, type 1, core

PFAM

PF00487

PRINTS

PR00075

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00767

PhosphoSite

PhosphoSite-O00767

TrEMBL

UniProt Splice Variant

Entrez Gene

6319

UniGene

Hs.734527

RefSeq

NP_005054

HUGO

HGNC:10571

OMIM

604031

CCDS

CCDS7493

HPRD

04941

IMGT

EMBL

AB032261 AF097514 AF320307 AK222862 AK312312 AL139819 BC005807 BC062303 CH471066 S70284 Y13647

GenPept

AAB30631 AAD29870 AAH05807 AAH62303 AAK54510 BAA93510 BAD96582 BAG35237 CAA73998 CAH72823 CAH72824 EAW49829 EAW49830