Version 5.4
Homo sapiens Gene: TREML2
Summary
InnateDB Gene IDBG-86610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREML2
Gene Name triggering receptor expressed on myeloid cells-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112195
Encoded Proteins
IDBP-482964
triggering receptor expressed on myeloid cells-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21804015
TLT2 enhances neutrophil functions such as antibacterial activity and chemotaxis by potentiating the response to the G protein-coupled receptor-signalling pathway.
InnateDB Annotation from Orthologs
Summary
PMID 21804015
[Mus musculus] Tlt2 enhances neutrophil functions such as antibacterial activity and chemotaxis by potentiating the response to the G protein-coupled receptor-signalling pathway.
Entrez Gene
Summary TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41190277-41201194
Strand Reverse strand
Band p21.1
Transcripts
ENST00000483722 ENSP00000418767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0042110 T cell activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071068
View Gene Order
ENSBTAG00000015707
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.164797
RefSeq NM_024807
HUGO
OMIM
CCDS CCDS4853
HPRD 11646
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca