Version 5.4
Homo sapiens Protein: TREML2
Summary
InnateDB Protein IDBP-482964.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREML2
Protein Name triggering receptor expressed on myeloid cells-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418767
InnateDB Gene IDBG-86610 (TREML2)
Protein Structure
UniProt Annotation
Function Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. {ECO:0000269PubMed:12645956, ECO:0000269PubMed:18650384}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. {ECO:0000269PubMed:12645956, ECO:0000269PubMed:18650384}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0042110 T cell activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T2D2
PhosphoSite PhosphoSite-Q5T2D2
TrEMBL
UniProt Splice Variant
Entrez Gene 79865
UniGene Hs.164797
RefSeq NP_079083
HUGO HGNC:21092
OMIM 609715
CCDS CCDS4853
HPRD 11646
IMGT
EMBL AF534824 AK023755 AL133404 AL391903 AY358171 BC125078 BC125079
GenPept AAI25079 AAI25080 AAO15022 AAQ88538 BAB14668 CAI19858 CAI19909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca