Version 5.4
Homo sapiens Gene: TREM1
Summary
InnateDB Gene IDBG-86629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREM1
Gene Name triggering receptor expressed on myeloid cells 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124731
Encoded Proteins
IDBP-86631
triggering receptor expressed on myeloid cells 1
IDBP-86633
triggering receptor expressed on myeloid cells 1
IDBP-719072
IDBP-719162
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20797396
TREM1 is a superimmunoglobulin receptor present on neutrophils and monocytes, which plays an important role in the amplification of inflammation and its expression is inhibited by PGD(2) and PGJ(2) in macrophages.
PMID 21393102
TREM1 is an activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by TLR4-signalling, specifically in the induction of TNFA production.
PMID 21555403
TREM1 expression is upregulated following Pseudomonas aeruginosa infection in the cornea and the inhibition of TREM1 reduces the severity of corneal disease. TREM1 acts as an inflammatory amplifier in P. aeruginosa keratitis by modulating TLR signalling and Th1/Th2 responses.
PMID 21690199
TREM1 expression is induced by vitamin D3 in human bronchial epithelial cells. Activation of TREM1 leads to the induction of human beta defensin 2 and TNF-alpha mRNA in the airway epithelium.
PMID 22459945
TREM1 mediates endotoxin tolerance in monocytes through its ability to induce anti- or pro-inflammatory signals depending on its membrane-bound state.
PMID 23475790
TREM1 expression and shedding are regulated by CpG-mediated TLR9 activation in macrophages.
PMID 25595774
PGLYRP1 binds to bacterially derived peptidoglycan and these complexes constitute potent ligands capable of binding to TREM1 and inducing myeloid cell functions.
Entrez Gene
Summary This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41267926-41286719
Strand Reverse strand
Band p21.1
Transcripts
ENST00000244709 ENSP00000244709
ENST00000334475 ENSP00000334284
ENST00000589614 ENSP00000465688
ENST00000589695
ENST00000591620 ENSP00000465345
ENST00000586287
ENST00000589882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0097110 scaffold protein binding
Biological Process
GO:0002374 cytokine secretion involved in immune response
GO:0006959 humoral immune response
GO:0007596 blood coagulation
GO:0016477 cell migration
GO:0030593 neutrophil chemotaxis
GO:0035556 intracellular signal transduction
GO:0042107 cytokine metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050755 chemokine metabolic process
GO:0050900 leukocyte migration
GO:0070945 neutrophil mediated killing of gram-negative bacterium
GO:0072672 neutrophil extravasation
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_147694
DAP12 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9NP99
TrEMBL
UniProt Splice Variant
Entrez Gene 54210
UniGene Hs.283022 Hs.674770
RefSeq NM_001242589 NM_001242590 NM_018643
HUGO HGNC:17760
OMIM 605085
CCDS CCDS59499 CCDS4854 CCDS56427
HPRD 05472
IMGT
EMBL AF196329 AF287008 AK223264 AK301519 AL391903 AY074783 BC017773
GenPept AAF71694 AAF90197 AAH17773 AAL74018 BAD96984 BAG63024 CAI19864
RNA Seq Atlas 54210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca