InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TREM1

Summary

InnateDB Protein

IDBP-86631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TREM1

Protein Name

triggering receptor expressed on myeloid cells 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000244709

InnateDB Gene

IDBG-86629 (TREM1)

Protein Structure

UniProt Annotation

Function

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. {ECO:0000269PubMed:10799849, ECO:0000269PubMed:11323674}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. {ECO:0000269PubMed:10799849, ECO:0000269PubMed:11922939}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0097110	scaffold protein binding

Biological Process

GO:0002374	cytokine secretion involved in immune response
GO:0006959	humoral immune response
GO:0007596	blood coagulation
GO:0016477	cell migration
GO:0030593	neutrophil chemotaxis
GO:0035556	intracellular signal transduction
GO:0042107	cytokine metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050755	chemokine metabolic process
GO:0050900	leukocyte migration
GO:0070945	neutrophil mediated killing of gram-negative bacterium
GO:0072672	neutrophil extravasation