Version 5.4
Homo sapiens Gene: GMEB2
Summary
InnateDB Gene IDBG-86705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMEB2
Gene Name glucocorticoid modulatory element binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101216
Encoded Proteins
IDBP-86707
glucocorticoid modulatory element binding protein 2
IDBP-86709
glucocorticoid modulatory element binding protein 2
IDBP-86711
glucocorticoid modulatory element binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63587602-63627041
Strand Reverse strand
Band q13.33
Transcripts
ENST00000370077 ENSP00000359094
ENST00000266068 ENSP00000266068
ENST00000370069 ENSP00000359086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038705
View Gene Order
ENSBTAG00000014769
Not yet available
Cross-References
SwissProt Q9UKD1
TrEMBL Q5JTV1 Q659E7
UniProt Splice Variant
Entrez Gene 26205
UniGene Hs.473286 Hs.604468
RefSeq NM_012384 XM_005260202 XM_006723776
HUGO HGNC:4371
OMIM 607451
CCDS CCDS13528
HPRD
IMGT
EMBL AB033095 AF173867 AL117510 AL121907 AL133646 AL353715 BC036305 CH471077
GenPept AAD51351 AAH36305 BAA86583 CAB63765 CAH56403 CAI17956 CAI22265 EAW75252 EAW75253 EAW75254
RNA Seq Atlas 26205

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca