InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GMEB2

Summary

InnateDB Protein

IDBP-86709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMEB2

Protein Name

glucocorticoid modulatory element binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000266068

InnateDB Gene

IDBG-86705 (GMEB2)

Protein Structure

UniProt Annotation

Function

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Subcellular Localization

Nucleus. Cytoplasm. Note=May be also cytoplasmic.

Disease Associations

Tissue Specificity

Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004871	signal transducer activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:2001141	regulation of RNA biosynthetic process