InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPC4

Summary

InnateDB Gene

IDBG-86726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPC4

Gene Name

glypican 4

Synonyms

K-glypican

Species

Homo sapiens

Ensembl Gene

ENSG00000076716

Encoded Proteins

IDBP-86728

glypican 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3\' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:133300103-133415490

Strand

Reverse strand

Band

q26.2

Transcripts

ENST00000370828

ENSP00000359864

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0008283	cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome