InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPC4

Summary

InnateDB Protein

IDBP-86728.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPC4

Protein Name

glypican 4

Synonyms

K-glypican;

Species

Homo sapiens

Ensembl Protein

ENSP00000359864

InnateDB Gene

IDBG-86726 (GPC4)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.Secreted glypican-4: Secreted, extracellular space {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0008283	cell proliferation
GO:0009653	anatomical structure morphogenesis
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome