Version 5.4
Homo sapiens Gene: GUCA1B
Summary
InnateDB Gene IDBG-87119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GUCA1B
Gene Name guanylate cyclase activator 1B (retina)
Synonyms GCAP2; GUCA2; RP48
Species Homo sapiens
Ensembl Gene ENSG00000112599
Encoded Proteins
IDBP-87121
guanylate cyclase activator 1B (retina)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42184401-42194916
Strand Reverse strand
Band p21.1
Transcripts
ENST00000230361 ENSP00000230361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0008048 calcium sensitive guanylate cyclase activator activity
GO:0030249 guanylate cyclase regulator activity
Biological Process
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007267 cell-cell signaling
GO:0007589 body fluid secretion
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0007603 phototransduction, visible light
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0031282 regulation of guanylate cyclase activity
GO:0031284 positive regulation of guanylate cyclase activity
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0097381 photoreceptor disc membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023979
View Gene Order
ENSBTAG00000012439
Not yet available
Pathways
NETPATH
REACTOME
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_163722
The phototransduction cascade pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_116125
Disease pathway
KEGG
hsa04740
Olfactory transduction pathway
hsa04744
Phototransduction pathway
INOH
PID NCI
Cross-References
SwissProt Q9UMX6
TrEMBL
UniProt Splice Variant
Entrez Gene 2979
UniGene Hs.446529
RefSeq NM_002098
HUGO HGNC:4679
OMIM 602275
CCDS CCDS4865
HPRD 03783
IMGT
EMBL AF173227 AF173228 AF173229 AL096814
GenPept AAD47279 CAB89166
RNA Seq Atlas 2979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca