Homo sapiens Gene: FGF8
Summary
InnateDB Gene IDBG-87424.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol FGF8
Gene Name fibroblast growth factor 8 (androgen-induced)
Synonyms AIGF; FGF-8; HBGF-8; HH6; KAL6;
Species Homo sapiens
Ensembl Gene ENSG00000107831
Encoded Proteins
fibroblast growth factor 8 (androgen-induced)
fibroblast growth factor 8 (androgen-induced)
fibroblast growth factor 8 (androgen-induced)
fibroblast growth factor 8 (androgen-induced)
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:103530081-103535827
Strand Reverse strand
Band q24.32
Transcripts
ENST00000320185 ENSP00000321797
ENST00000344255 ENSP00000340039
ENST00000347978 ENSP00000321945
ENST00000346714 ENSP00000344306
ENST00000485728
ENST00000469792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0000165 MAPK cascade
GO:0001569 patterning of blood vessels
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001839 neural plate morphogenesis
GO:0001947 heart looping
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0006915 apoptotic process
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007507 heart development
GO:0008078 mesodermal cell migration
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008406 gonad development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0009792 embryo development ending in birth or egg hatching
GO:0010628 positive regulation of gene expression
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021846 cell proliferation in forebrain
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030324 lung development
GO:0030509 BMP signaling pathway
GO:0030539 male genitalia development
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030917 midbrain-hindbrain boundary development
GO:0035050 embryonic heart tube development
GO:0035108 limb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035909 aorta morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045840 positive regulation of mitosis
GO:0046622 positive regulation of organ growth
GO:0048699 generation of neurons
GO:0048853 forebrain morphogenesis
GO:0051781 positive regulation of cell division
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060037 pharyngeal system development
GO:0060070 canonical Wnt receptor signaling pathway
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060348 bone development
GO:0060425 lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0071542 dopaminergic neuron differentiation
GO:0090134 cell migration involved in mesendoderm migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
FGFR2c ligand binding and activation pathway
FGFR3b ligand binding and activation pathway
FGFR3c ligand binding and activation pathway
FGFR1c ligand binding and activation pathway
FGFR4 ligand binding and activation pathway
Signaling by activated point mutants of FGFR1 pathway
Signaling by activated point mutants of FGFR3 pathway
KEGG
MAPK signaling pathway pathway
Melanoma pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
INOH
FGF signaling pathway pathway
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P55075
TrEMBL
UniProt Splice Variant
Entrez Gene 2253
UniGene Hs.57710
RefSeq NM_006119 NM_033163 NM_033164 NM_033165
HUGO 3686
OMIM 600483
CCDS CCDS7515 CCDS7516 CCDS7517 CCDS7518
HPRD 02727
IMGT
EMBL AB014615 AF520763 BC128235 CH471066 D38752 S78462 S78463 S78464 S78465 S78466 U36223 U36225 U36226 U36227 U36228 U46211 U46212 U46213 U47009 U47010 U47011 U56978
GenPept AAB03787 AAB17893 AAB17894 AAB34255 AAB40953 AAB40954 AAB40955 AAC50782 AAC50783 AAC50784 AAC50785 AAI28236 AAM55238 BAA22527 BAA28605 EAW49746
ImmGen FGF8 (murine)
RNA Seq Atlas 2253