Version 5.4
Mus musculus Gene: Fgf8
Summary
InnateDB Gene IDBG-171054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgf8
Gene Name fibroblast growth factor 8
Synonyms Aigf; Fgf-8
Species Mus musculus
Ensembl Gene ENSMUSG00000025219
Encoded Proteins
IDBP-171056
fibroblast growth factor 8
IDBP-171058
fibroblast growth factor 8
IDBP-257085
fibroblast growth factor 8
IDBP-257087
fibroblast growth factor 8
IDBP-257089
fibroblast growth factor 8
IDBP-257091
fibroblast growth factor 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107831:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45736798-45742915
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000026240 ENSMUSP00000026240
ENSMUST00000026241 ENSMUSP00000026241
ENSMUST00000111928 ENSMUSP00000107559
ENSMUST00000111927 ENSMUSP00000107558
ENSMUST00000111925 ENSMUSP00000107556
ENSMUST00000111924 ENSMUSP00000107555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000165 MAPK cascade
GO:0001569 patterning of blood vessels
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001759 organ induction
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001839 neural plate morphogenesis
GO:0001947 heart looping
GO:0001974 blood vessel remodeling
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007368 determination of left/right symmetry
GO:0007507 heart development
GO:0008045 motor neuron axon guidance
GO:0008078 mesodermal cell migration
GO:0008284 positive regulation of cell proliferation
GO:0008406 gonad development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009792 embryo development ending in birth or egg hatching
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021846 cell proliferation in forebrain
GO:0021884 forebrain neuron development
GO:0021954 central nervous system neuron development
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030324 lung development
GO:0030509 BMP signaling pathway
GO:0030539 male genitalia development
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030917 midbrain-hindbrain boundary development
GO:0033563 dorsal/ventral axon guidance
GO:0035050 embryonic heart tube development
GO:0035108 limb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035909 aorta morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045840 positive regulation of mitosis
GO:0046622 positive regulation of organ growth
GO:0048699 generation of neurons
GO:0048853 forebrain morphogenesis
GO:0050918 positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060037 pharyngeal system development
GO:0060070 canonical Wnt signaling pathway
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060348 bone development
GO:0060425 lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0071542 dopaminergic neuron differentiation
GO:0090134 cell migration involved in mesendoderm migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107831
View Gene Order
ENSBTAG00000001530
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_215603
FGFR3 ligand binding and activation pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_220750
FGFR3c ligand binding and activation pathway
REACT_212198
FGFR2 ligand binding and activation pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_198525
Negative regulation of FGFR signaling pathway
REACT_206694
FGFR4 ligand binding and activation pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_227330
FGFR ligand binding and activation pathway
REACT_242976
Signaling by EGFR pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_225874
FGFR1c ligand binding and activation pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_240139
PI3K Cascade pathway
REACT_196535
Signaling by FGFR2 mutants pathway
REACT_196536
Activated point mutants of FGFR2 pathway
REACT_196538
Signaling by activated point mutants of FGFR1 pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_213224
FGFR3b ligand binding and activation pathway
REACT_196455
Signaling by FGFR mutants pathway
REACT_196452
Signaling by FGFR1 mutants pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_94437
SHC-mediated cascade pathway
REACT_206286
GAB1 signalosome pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_206745
FGFR2c ligand binding and activation pathway
REACT_196505
Signaling by FGFR3 mutants pathway
REACT_196507
Signaling by activated point mutants of FGFR3 pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_216944
FGFR1 ligand binding and activation pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu05218
Melanoma pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL D3Z208
UniProt Splice Variant
Entrez Gene 14179
UniGene Mm.4012
RefSeq NM_001166361 NM_001166362 NM_001166363 NM_010205
OMIM
CCDS CCDS29864 CCDS50450 CCDS50451 CCDS50452
HPRD
IMGT
MGI ID MGI:99604
MGI Symbol Fgf8
EMBL AC149086
GenPept
RNA Seq Atlas 14179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca