Version 5.4
Homo sapiens Gene: TCEA2
Summary
InnateDB Gene IDBG-87740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCEA2
Gene Name transcription elongation factor A (SII), 2
Synonyms TFIIS
Species Homo sapiens
Ensembl Gene ENSG00000171703
Encoded Proteins
IDBP-87742
transcription elongation factor A (SII), 2
IDBP-87744
transcription elongation factor A (SII), 2
IDBP-87746
transcription elongation factor A (SII), 2
IDBP-240328
transcription elongation factor A (SII), 2
IDBP-381279
transcription elongation factor A (SII), 2
IDBP-381282
transcription elongation factor A (SII), 2
IDBP-381284
transcription elongation factor A (SII), 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:64049836-64072347
Strand Forward strand
Band q13.33
Transcripts
ENST00000361317 ENSP00000354552
ENST00000339217 ENSP00000339432
ENST00000343484 ENSP00000343515
ENST00000395053 ENSP00000378493
ENST00000415602 ENSP00000391807
ENST00000440819 ENSP00000407085
ENST00000458442 ENSP00000416026
ENST00000475792
ENST00000487164
ENST00000476113
ENST00000470559
ENST00000465111
ENST00000465433
ENST00000477783
ENST00000495168
ENST00000461072
ENST00000475236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003746 translation elongation factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006354 DNA-dependent transcription, elongation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006414 translational elongation
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0008023 transcription elongation factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059540
View Gene Order
ENSBTAG00000021836
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003195 NM_198723 XM_006723874
HUGO
OMIM
CCDS CCDS13553 CCDS13554
HPRD 16069
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca