Version 5.4
Homo sapiens Gene: PTK7
Summary
InnateDB Gene IDBG-87768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTK7
Gene Name PTK7 protein tyrosine kinase 7
Synonyms CCK-4; CCK4
Species Homo sapiens
Ensembl Gene ENSG00000112655
Encoded Proteins
IDBP-87770
PTK7 protein tyrosine kinase 7
IDBP-87772
PTK7 protein tyrosine kinase 7
IDBP-87776
PTK7 protein tyrosine kinase 7
IDBP-87778
PTK7 protein tyrosine kinase 7
IDBP-87780
PTK7 protein tyrosine kinase 7
IDBP-476207
PTK7 protein tyrosine kinase 7
IDBP-482784
PTK7 protein tyrosine kinase 7
IDBP-482840
PTK7 protein tyrosine kinase 7
IDBP-484223
PTK7 protein tyrosine kinase 7
IDBP-475535
PTK7 protein tyrosine kinase 7
IDBP-481721
PTK7 protein tyrosine kinase 7
IDBP-480816
PTK7 protein tyrosine kinase 7
IDBP-479036
PTK7 protein tyrosine kinase 7
IDBP-479345
PTK7 protein tyrosine kinase 7
IDBP-478674
PTK7 protein tyrosine kinase 7
IDBP-476783
PTK7 protein tyrosine kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43076268-43161719
Strand Forward strand
Band p21.1
Transcripts
ENST00000230419 ENSP00000230419
ENST00000345201 ENSP00000325992
ENST00000352931 ENSP00000326029
ENST00000230418 ENSP00000230418
ENST00000349241 ENSP00000325462
ENST00000476760 ENSP00000417607
ENST00000470019 ENSP00000420322
ENST00000471863 ENSP00000419037
ENST00000487673
ENST00000481273 ENSP00000418754
ENST00000481946 ENSP00000420165
ENST00000490710
ENST00000489707 ENSP00000420765
ENST00000470471
ENST00000493339
ENST00000494146 ENSP00000419096
ENST00000461100 ENSP00000418545
ENST00000497957 ENSP00000418462
ENST00000473339 ENSP00000420186
ENST00000461389 ENSP00000418386
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001736 establishment of planar polarity
GO:0001843 neural tube closure
GO:0003401 axis elongation
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0010976 positive regulation of neuron projection development
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0031532 actin cytoskeleton reorganization
GO:0042060 wound healing
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0060026 convergent extension
GO:0060070 canonical Wnt signaling pathway
GO:0060484 lung-associated mesenchyme development
GO:0071300 cellular response to retinoic acid
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023972
View Gene Order
ENSBTAG00000012761
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.90572
RefSeq NM_001270398 NM_002821 NM_152880 NM_152881 NM_152882
HUGO
OMIM
CCDS CCDS4884 CCDS4885 CCDS4886 CCDS4887 CCDS59021
HPRD 03534
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca