Version 5.4
Homo sapiens Gene: TAS1R1
Summary
InnateDB Gene IDBG-87969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAS1R1
Gene Name taste receptor, type 1, member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173662
Encoded Proteins
IDBP-87971
taste receptor, type 1, member 1
IDBP-87973
taste receptor, type 1, member 1
IDBP-87975
taste receptor, type 1, member 1
IDBP-365923
taste receptor, type 1, member 1
IDBP-365933
taste receptor, type 1, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6555181-6579757
Strand Forward strand
Band p36.31
Transcripts
ENST00000333172 ENSP00000331867
ENST00000328191 ENSP00000327705
ENST00000351136 ENSP00000312558
ENST00000411823 ENSP00000414166
ENST00000415267 ENSP00000408448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008527 taste receptor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0050917 sensory perception of umami taste
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028950
View Gene Order
ENSBTAG00000016734
Not yet available
Pathways
NETPATH
REACTOME
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.124574
RefSeq NM_138697 NM_177540
HUGO
OMIM
CCDS CCDS81 CCDS82
HPRD 06939
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca