InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PER3

Summary

InnateDB Gene

IDBG-88216.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PER3

Gene Name

period homolog 3 (Drosophila)

Synonyms

GIG13

Species

Homo sapiens

Ensembl Gene

ENSG00000049246

Encoded Proteins

IDBP-88218

period homolog 3 (Drosophila)

IDBP-88220

period homolog 3 (Drosophila)

IDBP-88222

period homolog 3 (Drosophila)

IDBP-812472

period circadian clock 3

IDBP-812474

period circadian clock 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:7784320-7845177

Strand

Forward strand

Band

p36.23

Transcripts

ENST00000377541	ENSP00000366764
ENST00000377532	ENSP00000366755
ENST00000361923	ENSP00000355031
ENST00000473653
ENST00000463106
ENST00000494684
ENST00000602883
ENST00000613533	ENSP00000482093
ENST00000614998	ENSP00000479223

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007623	circadian rhythm
GO:0032922	circadian regulation of gene expression
GO:0045187	regulation of circadian sleep/wake cycle, sleep

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000028957

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

hsa04710

Circadian rhythm pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001289861 NM_001289862 NM_001289863 NM_016831 XM_005263521 XM_005263522 XM_005263523 XM_005263527 XM_005263528 XM_005263529

HUGO

OMIM

CCDS

CCDS72695 CCDS89

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas