Version 5.4
Homo sapiens Gene: UTS2
Summary
InnateDB Gene IDBG-88258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UTS2
Gene Name urotensin 2
Synonyms PRO1068; U-II; UCN2; UII
Species Homo sapiens
Ensembl Gene ENSG00000049247
Encoded Proteins
IDBP-88260
urotensin 2
IDBP-88262
urotensin 2
IDBP-88264
urotensin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:7843083-7853512
Strand Reverse strand
Band p36.23
Transcripts
ENST00000377516 ENSP00000366738
ENST00000054668 ENSP00000054668
ENST00000361696 ENSP00000355163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0001666 response to hypoxia
GO:0003105 negative regulation of glomerular filtration
GO:0006936 muscle contraction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 synaptic transmission
GO:0008217 regulation of blood pressure
GO:0010459 negative regulation of heart rate
GO:0010460 positive regulation of heart rate
GO:0010763 positive regulation of fibroblast migration
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033574 response to testosterone
GO:0035811 negative regulation of urine volume
GO:0035814 negative regulation of renal sodium excretion
GO:0042312 regulation of vasodilation
GO:0042493 response to drug
GO:0045597 positive regulation of cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep
GO:0046676 negative regulation of insulin secretion
GO:0048146 positive regulation of fibroblast proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.715862
RefSeq NM_006786 NM_021995
HUGO
OMIM
CCDS CCDS90 CCDS91
HPRD 04976
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca