Homo sapiens Protein: UTS2
Summary
InnateDB Protein IDBP-88262.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UTS2
Protein Name urotensin 2
Synonyms PRO1068; U-II; UCN2; UII;
Species Homo sapiens
Ensembl Protein ENSP00000054668
InnateDB Gene IDBG-88258 (UTS2)
Protein Structure
UniProt Annotation
Function Highly potent vasoconstrictor.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Brain specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0001666 response to hypoxia
GO:0003105 negative regulation of glomerular filtration
GO:0006936 muscle contraction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 synaptic transmission
GO:0008217 regulation of blood pressure
GO:0010459 negative regulation of heart rate
GO:0010460 positive regulation of heart rate
GO:0010763 positive regulation of fibroblast migration
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033574 response to testosterone
GO:0035811 negative regulation of urine volume
GO:0035814 negative regulation of renal sodium excretion
GO:0042312 regulation of vasodilation
GO:0042493 response to drug
GO:0045597 positive regulation of cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0045777 positive regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep
GO:0046676 negative regulation of insulin secretion
GO:0048146 positive regulation of fibroblast proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001483 Urotensin II
PFAM PF02083
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95399
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 10911
UniGene Hs.715862
RefSeq NP_068835
HUGO HGNC:12636
OMIM 604097
CCDS CCDS90
HPRD 04976
IMGT
EMBL AF104118 AF140630 AY358375 Z98884
GenPept AAD13070 AAD55577 AAQ88741 CAB63148 CAI21438