Version 5.4
Homo sapiens Gene: WDR34
Summary
InnateDB Gene IDBG-88472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR34
Gene Name WD repeat domain 34
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119333
Encoded Proteins
IDBP-88474
WD repeat domain 34
IDBP-381821
WD repeat domain 34
IDBP-381824
WD repeat domain 34
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19521662
WDR34 is a MAP3K7 (TAK1)-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:128633661-128656787
Strand Reverse strand
Band q34.11
Transcripts
ENST00000372715 ENSP00000361800
ENST00000451652 ENSP00000411370
ENST00000419989 ENSP00000415421
ENST00000483181
ENST00000480613
ENST00000473486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005814 centriole
GO:0005930 axoneme
GO:0036064 ciliary basal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039715
View Gene Order
ENSBTAG00000015343
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_052844
HUGO
OMIM
CCDS CCDS6906
HPRD 15666
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca