Version 5.4
Homo sapiens Gene: DOLK
Summary
InnateDB Gene IDBG-88831.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOLK
Gene Name dolichol kinase
Synonyms CDG1M; DK; DK1; SEC59; TMEM15
Species Homo sapiens
Ensembl Gene ENSG00000175283
Encoded Proteins
IDBP-88833
dolichol kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:128945530-128947619
Strand Reverse strand
Band q34.11
Transcripts
ENST00000372586 ENSP00000361667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004168 dolichol kinase activity
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0006489 dolichyl diphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043048 dolichyl monophosphate biosynthetic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000075419
View Gene Order
ENSBTAG00000010601
Not yet available
Pathways
NETPATH
REACTOME
REACT_22230
Synthesis of Dolichyl-phosphate pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9UPQ8
TrEMBL
UniProt Splice Variant
Entrez Gene 22845
UniGene Hs.531563
RefSeq NM_014908
HUGO HGNC:23406
OMIM 610746
CCDS CCDS6915
HPRD 15525
IMGT
EMBL AB029017 AL672142 AY358759 BC035556
GenPept AAH35556 AAQ89119 BAA83046 CAI10844
RNA Seq Atlas 22845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca