InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APITD1

Summary

InnateDB Gene

IDBG-89014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APITD1

Gene Name

apoptosis-inducing, TAF9-like domain 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000175279

Encoded Proteins

IDBP-89020

apoptosis-inducing, TAF9-like domain 1

IDBP-721755

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011] This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:10430443-10442809

Strand

Forward strand

Band

p36.22

Transcripts

ENST00000309048	ENSP00000308583
ENST00000477755	ENSP00000468629
ENST00000462462
ENST00000464507
ENST00000602486

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000712	resolution of meiotic recombination intermediates
GO:0006281	DNA repair
GO:0006352	DNA-templated transcription, initiation
GO:0006974	cellular response to DNA damage stimulus
GO:0007067	mitotic nuclear division
GO:0031297	replication fork processing
GO:0031398	positive regulation of protein ubiquitination