InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APITD1

Summary

InnateDB Protein

IDBP-89020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APITD1

Protein Name

apoptosis-inducing, TAF9-like domain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000308583

InnateDB Gene

IDBG-89014 (APITD1)

Protein Structure

UniProt Annotation

Function

DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. {ECO:0000269PubMed:19620631, ECO:0000269Ref.7, ECO:0000269Ref.8}.

Subcellular Localization

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:15328517}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000712	resolution of meiotic recombination intermediates
GO:0006281	DNA repair
GO:0006352	DNA-templated transcription, initiation
GO:0006974	cellular response to DNA damage stimulus
GO:0007067	mitotic nuclear division
GO:0031297	replication fork processing
GO:0031398	positive regulation of protein ubiquitination