Version 5.4
Homo sapiens Gene: MAGEA6
Summary
InnateDB Gene IDBG-89279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGEA6
Gene Name melanoma antigen family A, 6
Synonyms CT1.6; MAGE-3b; MAGE3B; MAGE6
Species Homo sapiens
Ensembl Gene ENSG00000197172
Encoded Proteins
IDBP-89151
melanoma antigen family A, 6
IDBP-382526
melanoma antigen family A, 6
IDBP-382528
melanoma antigen family A, 6
IDBP-812902
melanoma antigen family A, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80%% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:152766136-152769747
Strand Reverse strand
Band q28
Transcripts
ENST00000329342 ENSP00000329199
ENST00000412733 ENSP00000403303
ENST00000457643 ENSP00000401806
ENST00000616035 ENSP00000480637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL B9A060 E7ETG4 E7EUF2
UniProt Splice Variant
Entrez Gene 4105
UniGene
RefSeq NM_005363 NM_175868
HUGO HGNC:6804
OMIM 300176
CCDS CCDS76050
HPRD 02168
IMGT
EMBL AF002997
GenPept
RNA Seq Atlas 4105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca