Version 5.4
Homo sapiens Protein: MAGEA6
Summary
InnateDB Protein IDBP-89151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGEA6
Protein Name melanoma antigen family A, 6
Synonyms CT1.6; MAGE-3b; MAGE3B; MAGE6;
Species Homo sapiens
Ensembl Protein ENSP00000329199
InnateDB Gene IDBG-89279 (MAGEA6)
Protein Structure
UniProt Annotation
Function Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. {ECO:0000269PubMed:17942928, ECO:0000269PubMed:20864041}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR002190 MAGE protein
IPR021072 Melanoma associated antigen, MAGE, N-terminal
PFAM PF01454
PF12440
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43360
PhosphoSite PhosphoSite-P43360
TrEMBL E7EUF2
UniProt Splice Variant
Entrez Gene 4105
UniGene
RefSeq NP_005354
HUGO HGNC:6804
OMIM 300176
CCDS CCDS76050
HPRD 02168
IMGT
EMBL AF002997 BC041599 BC067731 BX640600 D32076 EU161101 U10339 U10691
GenPept AAA19006 AAA68875 AAH41599 AAH67731 ABW06860 BAA06842 CAE45706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca