InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CETN2

Summary

InnateDB Gene

IDBG-89287.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CETN2

Gene Name

centrin, EF-hand protein, 2

Synonyms

CALT; CEN2

Species

Homo sapiens

Ensembl Gene

ENSG00000147400

Encoded Proteins

IDBP-89289

centrin, EF-hand protein, 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:152826973-152830777

Strand

Reverse strand

Band

q28

Transcripts

ENST00000370277	ENSP00000359300
ENST00000493482

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008026	ATP-dependent helicase activity
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0032795	heterotrimeric G-protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006289	nucleotide-excision repair
GO:0007067	mitotic nuclear division
GO:0007099	centriole replication
GO:0007283	spermatogenesis
GO:0032465	regulation of cytokinesis

Cellular Component

GO:0005622	intracellular
GO:0005813	centrosome
GO:0005814	centriole
GO:0005829	cytosol
GO:0005929	cilium
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0071942	XPC complex