InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CETN2

Summary

InnateDB Protein

IDBP-89289.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CETN2

Protein Name

centrin, EF-hand protein, 2

Synonyms

CALT; CEN2;

Species

Homo sapiens

Ensembl Protein

ENSP00000359300

InnateDB Gene

IDBG-89287 (CETN2)

Protein Structure

UniProt Annotation

Function

Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus {ECO:0000305}. Note=Centrosome of S-phase, interphase and mitotic cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008026	ATP-dependent helicase activity
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0032795	heterotrimeric G-protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006289	nucleotide-excision repair
GO:0007067	mitotic nuclear division
GO:0007099	centriole replication
GO:0007283	spermatogenesis
GO:0032465	regulation of cytokinesis

Cellular Component

GO:0005622	intracellular
GO:0005813	centrosome
GO:0005814	centriole
GO:0005829	cytosol
GO:0005929	cilium
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0071942	XPC complex