Version 5.4
Homo sapiens Gene: USP20
Summary
InnateDB Gene IDBG-89323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP20
Gene Name ubiquitin specific peptidase 20
Synonyms hVDU2; LSFR3A; VDU2
Species Homo sapiens
Ensembl Gene ENSG00000136878
Encoded Proteins
IDBP-89325
ubiquitin specific peptidase 20
IDBP-89327
ubiquitin specific peptidase 20
IDBP-89329
ubiquitin specific peptidase 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:129834698-129881838
Strand Forward strand
Band q34.11
Transcripts
ENST00000372429 ENSP00000361506
ENST00000315480 ENSP00000313811
ENST00000358355 ENSP00000351122
ENST00000491053
ENST00000494971
ENST00000474895
ENST00000491731
ENST00000496927
ENST00000472108
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006897 endocytosis
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0016579 protein deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005813 centrosome
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026854
View Gene Order
ENSBTAG00000020311
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5452
RefSeq NM_001008563 NM_001110303 NM_006676
HUGO
OMIM
CCDS CCDS43892
HPRD 07505
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca