Version 5.4
| Homo sapiens Gene: FBXO44 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-89443.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FBXO44 | ||||||||||||||||||
| Gene Name | F-box protein 44 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000132879 | ||||||||||||||||||
| Encoded Proteins |
F-box protein 44
F-box protein 44
F-box protein 44
F-box protein 44
F-box protein 44
F-box protein 44
F-box protein 44
F-box protein 44
F-box protein 44
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Four alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:11654375-11663327 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p36.22 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9H4M3 | ||||||||||||||||||
| TrEMBL | A0A024R4F9 A0A024R4J6 B7Z1P2 B7Z1X4 R4GNH4 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 93611 | ||||||||||||||||||
| UniGene | Hs.556006 | ||||||||||||||||||
| RefSeq | NM_001014765 NM_033182 NM_183412 NM_183413 XM_005263538 XM_006711043 XM_006711044 XM_006711046 XM_006711047 | ||||||||||||||||||
| HUGO | HGNC:24847 | ||||||||||||||||||
| OMIM | 609111 | ||||||||||||||||||
| CCDS | CCDS131 CCDS132 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK055344 AK293721 AK294053 AK301418 AK316284 AL031731 AY007380 AY040878 BC007832 CH471130 CR749368 | ||||||||||||||||||
| GenPept | AAG09623 AAH07832 AAK77940 BAG51504 BAH11578 BAH11660 BAH13479 BAH14655 CAH18221 CAI20210 CAI20211 CAI20212 CAI20213 EAW71690 EAW71691 EAW71692 EAW71693 EAW71694 EAW71695 | ||||||||||||||||||
| RNA Seq Atlas | 93611 | ||||||||||||||||||