Version 5.4
Homo sapiens Gene: CATSPER2
Summary
InnateDB Gene IDBG-8968.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CATSPER2
Gene Name cation channel, sperm associated 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166762
Encoded Proteins
IDBP-8970
cation channel, sperm associated 2
IDBP-8978
cation channel, sperm associated 2
IDBP-236563
cation channel, sperm associated 2
IDBP-294777
cation channel, sperm associated 2
IDBP-370523
cation channel, sperm associated 2
IDBP-370542
cation channel, sperm associated 2
IDBP-370546
cation channel, sperm associated 2
IDBP-370551
cation channel, sperm associated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:43628503-43668118
Strand Reverse strand
Band q15.3
Transcripts
ENST00000381761 ENSP00000371180
ENST00000321596 ENSP00000321463
ENST00000396879 ENSP00000380088
ENST00000409481 ENSP00000386595
ENST00000450810 ENSP00000388242
ENST00000433380 ENSP00000389746
ENST00000419262 ENSP00000408240
ENST00000432420 ENSP00000407694
ENST00000415968
ENST00000469461
ENST00000472960
ENST00000464721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0030154 cell differentiation
GO:0030317 sperm motility
GO:0032504 multicellular organism reproduction
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035036 sperm-egg recognition
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0036128 CatSper complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033486
View Gene Order
ENSBTAG00000032130
Not yet available
Pathways
NETPATH
REACTOME
REACT_163914
Fertilization pathway
REACT_163875
Sperm Motility And Taxes pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.606904 Hs.662284 Hs.686921
RefSeq NM_001282309 NM_001282310 NM_054020 NM_172095
HUGO
OMIM
CCDS CCDS10099 CCDS32216 CCDS73714
HPRD 16236
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca