Version 5.4
Mus musculus Gene: Catsper2
Summary
InnateDB Gene IDBG-202235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Catsper2
Gene Name cation channel, sperm associated 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033486
Encoded Proteins
IDBP-202239
cation channel, sperm associated 2
IDBP-534037
cation channel, sperm associated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166762:
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:121392631-121413792
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000038073 ENSMUSP00000037222
ENSMUST00000154604 ENSMUSP00000119091
ENSMUST00000146521
ENSMUST00000123982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006811 ion transport
GO:0009566 fertilization
GO:0030317 sperm motility
GO:0048240 sperm capacitation
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0016020 membrane
GO:0036126 sperm flagellum
GO:0036128 CatSper complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166762
View Gene Order
ENSBTAG00000032130
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163914
Fertilization pathway
REACT_163875
Sperm Motility And Taxes pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_153075 XM_006499080 XM_006499081
OMIM
CCDS CCDS38216
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca