InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACSL5

Summary

InnateDB Gene

IDBG-89780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL5

Gene Name

acyl-CoA synthetase long-chain family member 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000197142

Encoded Proteins

IDBP-89782

acyl-CoA synthetase long-chain family member 5

IDBP-89786

acyl-CoA synthetase long-chain family member 5

IDBP-89788

acyl-CoA synthetase long-chain family member 5

IDBP-244336

acyl-CoA synthetase long-chain family member 5

IDBP-385492

acyl-CoA synthetase long-chain family member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:112374018-112428380

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000354655	ENSP00000346680
ENST00000356116	ENSP00000348429
ENST00000354273	ENSP00000346223
ENST00000393081	ENSP00000376796
ENST00000433418	ENSP00000403647
ENST00000479936
ENST00000495539
ENST00000467340
ENST00000496328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0008152	metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:2001236	regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024981

View Gene Order

ENSBTAG00000006707

Not yet available

Pathways

NETPATH

REACTOME

REACT_380

Synthesis of very long-chain fatty acyl-CoAs pathway

REACT_1319

Fatty Acyl-CoA Biosynthesis pathway

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00061

Fatty acid biosynthesis pathway

hsa00071

Fatty acid degradation pathway

hsa03320

PPAR signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.11638

RefSeq

NM_016234 NM_203379 NM_203380

HUGO

OMIM

CCDS

CCDS7572 CCDS7573

HPRD

16139

IMGT

EMBL

GenPept

RNA Seq Atlas