InnateDB Protein
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IDBP-89782.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ACSL5
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Protein Name
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acyl-CoA synthetase long-chain family member 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000346680
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InnateDB Gene
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IDBG-89780 (ACSL5)
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Protein Structure
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Function |
Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269PubMed:17681178, ECO:0000269PubMed:18806831, ECO:0000269PubMed:19459852}.
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Subcellular Localization |
Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000873
AMP-dependent synthetase/ligase
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PFAM |
PF00501
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ULC5
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PhosphoSite |
PhosphoSite-Q9ULC5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51703
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UniGene |
Hs.11638
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RefSeq |
NP_976313
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HUGO |
HGNC:16526
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OMIM |
605677
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CCDS |
CCDS7573
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HPRD |
16139
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IMGT |
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EMBL |
AB033899
AB033920
AK000339
AK222782
AL157786
AM262166
AY358520
BC007985
CH471066
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GenPept |
AAH07985
AAQ88884
BAA85979
BAA86054
CAH72510
CAK18174
EAW49532
EAW49535
EAW49536
EAW49539
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