Version 5.4
Homo sapiens Gene: SLC25A27
Summary
InnateDB Gene IDBG-89913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A27
Gene Name solute carrier family 25, member 27
Synonyms UCP4
Species Homo sapiens
Ensembl Gene ENSG00000153291
Encoded Proteins
IDBP-89915
solute carrier family 25, member 27
IDBP-380920
solute carrier family 25, member 27
IDBP-810592
solute carrier family 25, member 27
IDBP-810593
solute carrier family 25, member 27
IDBP-810594
solute carrier family 25, member 27
IDBP-810595
solute carrier family 25, member 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:46652915-46678193
Strand Forward strand
Band p12.3
Transcripts
ENST00000371347 ENSP00000360398
ENST00000411689 ENSP00000412024
ENST00000603486 ENSP00000474781
ENST00000604908
ENST00000604217 ENSP00000474429
ENST00000604127 ENSP00000474828
ENST00000604616 ENSP00000473804
ENST00000603501
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006810 transport
GO:0008284 positive regulation of cell proliferation
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0035356 cellular triglyceride homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0046324 regulation of glucose import
GO:0048839 inner ear development
GO:0051562 negative regulation of mitochondrial calcium ion concentration
GO:0070997 neuron death
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023912
View Gene Order
ENSBTAG00000016302
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001204051 NM_001204052 NM_004277 XM_005249485
HUGO
OMIM
CCDS CCDS43470 CCDS56431
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca