InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A27

Summary

InnateDB Protein

IDBP-89915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A27

Protein Name

solute carrier family 25, member 27

Synonyms

UCP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000360398

InnateDB Gene

IDBG-89913 (SLC25A27)

Protein Structure

UniProt Annotation

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006810	transport
GO:0008284	positive regulation of cell proliferation
GO:0010917	negative regulation of mitochondrial membrane potential
GO:0035356	cellular triglyceride homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0046324	regulation of glucose import
GO:0048839	inner ear development
GO:0051562	negative regulation of mitochondrial calcium ion concentration
GO:0070997	neuron death

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0045177	apical part of cell