Version 5.4
Homo sapiens Gene: SNX13
Summary
InnateDB Gene IDBG-9019.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX13
Gene Name sorting nexin 13
Synonyms RGS-PX1
Species Homo sapiens
Ensembl Gene ENSG00000071189
Encoded Proteins
IDBP-295038
sorting nexin 13
IDBP-295033
sorting nexin 13
IDBP-366475
sorting nexin 13
IDBP-366501
sorting nexin 13
IDBP-808539
sorting nexin 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:17790761-17940501
Strand Reverse strand
Band p21.1
Transcripts
ENST00000409076 ENSP00000387053
ENST00000409604 ENSP00000386639
ENST00000428135 ENSP00000398789
ENST00000444712 ENSP00000397768
ENST00000496855
ENST00000482558
ENST00000492626
ENST00000474067
ENST00000475800
ENST00000498463
ENST00000494402
ENST00000471744
ENST00000611725 ENSP00000479044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0005769 early endosome
GO:0031901 early endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020590
View Gene Order
ENSBTAG00000014074
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487648
RefSeq NM_015132
HUGO
OMIM
CCDS CCDS47551
HPRD 09418
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca