InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX13

Summary

InnateDB Protein

IDBP-366475.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX13

Protein Name

sorting nexin 13

Synonyms

RGS-PX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000398789

InnateDB Gene

IDBG-9019 (SNX13)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas. {ECO:0000250, ECO:0000269PubMed:11729322}.

Subcellular Localization

Early endosome membrane {ECO:0000269PubMed:11729322}; Peripheral membrane protein {ECO:0000269PubMed:11729322}; Cytoplasmic side {ECO:0000269PubMed:11729322}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005769	early endosome
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001683 Phox homologous domain
IPR003114 Phox-associated domain
IPR003204 Cytochrome c oxidase, subunit Va/VI
IPR013937 Sorting nexin, C-terminal
IPR013996 PX-associated, sorting nexin 13
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00787
PF02194
PF02284
PF08628

PRINTS

PR01301

PIRSF

SMART

SM00312
SM00313
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt