InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CEL

Summary

InnateDB Gene

IDBG-90630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEL

Gene Name

carboxyl ester lipase (bile salt-stimulated lipase)

Synonyms

BAL; BSDL; BSSL; CEase; CELL; FAP; FAPP; LIPA; MODY8

Species

Homo sapiens

Ensembl Gene

ENSG00000170835

Encoded Proteins

IDBP-90632

carboxyl ester lipase (bile salt-stimulated lipase)

IDBP-90636

carboxyl ester lipase (bile salt-stimulated lipase)

IDBP-811185

carboxyl ester lipase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:133061978-133087355

Strand

Forward strand

Band

q34.13

Transcripts

ENST00000372080	ENSP00000361151
ENST00000351304	ENSP00000342217
ENST00000621209	ENSP00000480238

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004771	sterol esterase activity
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016787	hydrolase activity
GO:0047372	acylglycerol lipase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006707	cholesterol catabolic process
GO:0008152	metabolic process
GO:0009062	fatty acid catabolic process
GO:0018350	protein esterification
GO:0030157	pancreatic juice secretion
GO:0030299	intestinal cholesterol absorption
GO:0044241	lipid digestion
GO:0044258	intestinal lipid catabolic process
GO:0044281	small molecule metabolic process
GO:0046514	ceramide catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026818

View Gene Order

ENSBTAG00000007486

Not yet available

Pathways

NETPATH

REACTOME

REACT_9518

Digestion of dietary lipid pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

REACT_602

Lipid digestion, mobilization, and transport pathway

KEGG

hsa00100

Steroid biosynthesis pathway

hsa00561

Glycerolipid metabolism pathway

hsa04975

Fat digestion and absorption pathway

hsa04972

Pancreatic secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001807

HUGO

OMIM

CCDS

CCDS43896

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas