InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RANGAP1

Summary

InnateDB Gene

IDBG-9064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RANGAP1

Gene Name

Ran GTPase activating protein 1

Synonyms

Fug1; RANGAP; SD

Species

Homo sapiens

Ensembl Gene

ENSG00000100401

Encoded Proteins

IDBP-9068

Ran GTPase activating protein 1

IDBP-293286

Ran GTPase activating protein 1

IDBP-378004

Ran GTPase activating protein 1

IDBP-378005

Ran GTPase activating protein 1

IDBP-378006

Ran GTPase activating protein 1

IDBP-378007

Ran GTPase activating protein 1

IDBP-378008

Ran GTPase activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq, Jul 2008]
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:41245611-41286251

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000356244	ENSP00000348577
ENST00000405486	ENSP00000385866
ENST00000455915	ENSP00000401470
ENST00000446258	ENSP00000393407
ENST00000452543	ENSP00000394787
ENST00000418067	ENSP00000408743
ENST00000422838	ENSP00000404842

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	94 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005098	Ran GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007165	signal transduction
GO:0032853	positive regulation of Ran GTPase activity
GO:0046826	negative regulation of protein export from nucleus

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm