Version 5.4
Homo sapiens Protein: RANGAP1
Summary
InnateDB Protein IDBP-293286.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RANGAP1
Protein Name Ran GTPase activating protein 1
Synonyms Fug1; RANGAP; SD;
Species Homo sapiens
Ensembl Protein ENSP00000385866
InnateDB Gene IDBG-9064 (RANGAP1)
Protein Structure
UniProt Annotation
Function GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Subcellular Localization Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
Disease Associations
Tissue Specificity Highly expressed in brain, thymus and testis. {ECO:0000269PubMed:8973340}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 94 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005098 Ran GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007165 signal transduction
GO:0032853 positive regulation of Ran GTPase activity
GO:0046826 negative regulation of protein export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR009109 Ran-GTPase activating protein 1, C-terminal
PFAM PF07834
PRINTS
PIRSF
SMART SM00368
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46060
PhosphoSite PhosphoSite-P46060
TrEMBL Q9BSK3
UniProt Splice Variant
Entrez Gene 5905
UniGene Hs.734461
RefSeq NP_001265580
HUGO HGNC:9854
OMIM 602362
CCDS CCDS14012
HPRD 03839
IMGT
EMBL AB058738 AK303524 AL035681 BC004990 BC014044 BC019676 BC041396 CH471095 CR456557 X82260
GenPept AAH04990 AAH14044 AAH19676 AAH41396 BAB47464 BAG64552 CAA57714 CAB63073 CAG30443 EAW60423 EAW60424

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca