Version 5.4
Homo sapiens Gene: RALGDS
Summary
InnateDB Gene IDBG-90728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RALGDS
Gene Name ral guanine nucleotide dissociation stimulator
Synonyms RalGEF; RGDS; RGF
Species Homo sapiens
Ensembl Gene ENSG00000160271
Encoded Proteins
IDBP-90730
ral guanine nucleotide dissociation stimulator
IDBP-90734
ral guanine nucleotide dissociation stimulator
IDBP-90736
ral guanine nucleotide dissociation stimulator
IDBP-244187
ral guanine nucleotide dissociation stimulator
IDBP-244189
ral guanine nucleotide dissociation stimulator
IDBP-383239
ral guanine nucleotide dissociation stimulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:133097720-133149334
Strand Reverse strand
Band q34.2
Transcripts
ENST00000372062 ENSP00000361132
ENST00000372050 ENSP00000361120
ENST00000372047 ENSP00000361117
ENST00000393160 ENSP00000376867
ENST00000393157 ENSP00000376864
ENST00000424572 ENSP00000391814
ENST00000493438
ENST00000482648
ENST00000469972
ENST00000498797
ENST00000495621
ENST00000477660
ENST00000471109
ENST00000493067
ENST00000460587
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026821
View Gene Order
ENSBTAG00000004194
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_23
TSH pathway
REACTOME
REACT_12065
p38MAPK events pathway
REACT_12033
Signalling to RAS pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.106185
RefSeq NM_001042368 NM_001271774 NM_001271775 NM_001271776 NM_006266
HUGO
OMIM
CCDS CCDS43897 CCDS65172 CCDS65173 CCDS65174 CCDS6959
HPRD 03371
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca