InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL10

Summary

InnateDB Gene

IDBG-91249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL10

Gene Name

ribosomal protein L10

Synonyms

AUTSX5; DXS648; DXS648E; L10; NOV; QM

Species

Homo sapiens

Ensembl Gene

ENSG00000147403

Encoded Proteins

IDBP-91251

ribosomal protein L10

IDBP-91253

ribosomal protein L10

IDBP-294239

ribosomal protein L10

IDBP-383540

ribosomal protein L10

IDBP-383542

ribosomal protein L10

IDBP-383543

ribosomal protein L10

IDBP-383544

ribosomal protein L10

IDBP-383545

ribosomal protein L10

IDBP-383546

ribosomal protein L10

IDBP-383548

ribosomal protein L10

IDBP-810129

ribosomal protein L10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Alternative splicing results in multiple transcript variants. This gene also uses multiple polyA signals, with the 3'-most polyA signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2012]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as \'laminin receptor homolog\' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Alternative splicing results in multiple transcript variants. This gene also uses multiple polyA signals, with the 3\'-most polyA signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:154389955-154409168

Strand

Forward strand

Band

q28

Transcripts

ENST00000369817	ENSP00000358832
ENST00000344746	ENSP00000341730
ENST00000406022	ENSP00000385621
ENST00000436473	ENSP00000388600
ENST00000424325	ENSP00000413436
ENST00000458500	ENSP00000395025
ENST00000451365	ENSP00000406125
ENST00000428169	ENSP00000398047
ENST00000427682	ENSP00000405064
ENST00000449494	ENSP00000407754
ENST00000474786
ENST00000479366
ENST00000491035
ENST00000489200
ENST00000485196
ENST00000482732
ENST00000492572
ENST00000467168
ENST00000618723	ENSP00000479103

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.

Experimentally validated
Total	95 [view]
Protein-Protein	92 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit