Homo sapiens Gene: RPL10
Summary
InnateDB Gene IDBG-91249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL10
Gene Name ribosomal protein L10
Synonyms AUTSX5; DXS648; DXS648E; L10; NOV; QM;
Species Homo sapiens
Ensembl Gene ENSG00000147403
Encoded Proteins
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
ribosomal protein L10
Protein Structure
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Alternative splicing results in multiple transcript variants. This gene also uses multiple polyA signals, with the 3'-most polyA signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2012]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as \'laminin receptor homolog\' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Alternative splicing results in multiple transcript variants. This gene also uses multiple polyA signals, with the 3\'-most polyA signal overlapping the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154389955-154409168
Strand Forward strand
Band q28
Transcripts
ENST00000369817 ENSP00000358832
ENST00000344746 ENSP00000341730
ENST00000406022 ENSP00000385621
ENST00000436473 ENSP00000388600
ENST00000424325 ENSP00000413436
ENST00000458500 ENSP00000395025
ENST00000451365 ENSP00000406125
ENST00000428169 ENSP00000398047
ENST00000427682 ENSP00000405064
ENST00000449494 ENSP00000407754
ENST00000474786
ENST00000479366
ENST00000491035
ENST00000489200
ENST00000485196
ENST00000482732
ENST00000492572
ENST00000467168
ENST00000618723 ENSP00000479103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
Experimentally validated
Total 95 [view]
Protein-Protein 92 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P27635
TrEMBL B8A6G2 H7C123 H7C2C5 H7C2U2 X1WI28 X5D2T3 X5D2W5
UniProt Splice Variant
Entrez Gene 6134
UniGene Hs.534404 Hs.739235
RefSeq NM_001256577 NM_001256580 NM_006013
HUGO HGNC:10298
OMIM 312173
CCDS CCDS14746 CCDS76059
HPRD 02421
IMGT
EMBL AB007170 AF486812 AK223309 BC003358 BC026276 BC071918 BX936346 BX936347 CH471172 CR456797 CR542069 DQ369703 DQ369704 DQ369705 DQ369706 DQ369707 DQ369708 DQ369709 DQ369710 DQ369711 DQ369712 DQ369713 DQ369714 DQ369715 DQ369716 KJ534934 KJ534979 L44140 M64241 M73791 M81806 S35960 S64168 S64169
GenPept AAA36021 AAA36378 AAA63253 AAA92646 AAB22173 AAB27665 AAH03358 AAH26276 AAH71918 AAL88713 ABC88559 ABC88560 ABC88561 ABC88562 ABC88563 ABC88564 ABC88565 ABC88566 ABC88567 ABC88568 ABC88569 ABC88570 ABC88571 ABC88572 AHW56574 AHW56619 BAA28595 BAD97029 CAG33078 CAG46866 CAI43214 CAI43230 CAM45852 CAM45853 EAW72737 EAW72739
ImmGen RPL10 (murine)
RNA Seq Atlas 26778 6134